Hypertension, Nitrate-Nitrite, and Xanthine Oxidoreductase Catalyzed Nitric Oxide Generation: Pros and Cons
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Hypertension, nitrate-nitrite, and xanthine oxidoreductase catalyzed nitric oxide generation: pros and cons.
Hypertension, Nitrate-Nitrite, and Xanthine Oxidoreductase Catalyzed Nitric Oxide Generation: Pros and Cons We read with great interest the article by Ghosh et al1 on the use of beetroot juice as a potential therapy for hypertension. This article proposes the intriguing concept that dietary nitrate in beetroot juice can be converted into therapeutically beneficial nitric oxide (NO) for use in t...
متن کاملDietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.
BACKGROUND Pulmonary hypertension (PH) is a multifactorial disease characterized by increased pulmonary vascular resistance and right ventricular failure; morbidity and mortality remain unacceptably high. Loss of nitric oxide (NO) bioactivity is thought to contribute to the pathogenesis of PH, and agents that augment pulmonary NO signaling are clinically effective in the disease. Inorganic nitr...
متن کاملVascular Medicine Dietary Nitrate Ameliorates Pulmonary Hypertension Cytoprotective Role for Endothelial Nitric Oxide Synthase and Xanthine Oxidoreductase
Background—Pulmonary hypertension (PH) is a multifactorial disease characterized by increased pulmonary vascular resistance and right ventricular failure; morbidity and mortality remain unacceptably high. Loss of nitric oxide (NO) bioactivity is thought to contribute to the pathogenesis of PH, and agents that augment pulmonary NO signaling are clinically effective in the disease. Inorganic nitr...
متن کاملSuicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide.
Xanthine oxidoreductase (XOR) is progressively inactivated while catalysing the reduction of inorganic nitrite to NO by xanthine. Inactivation results from conversion of the enzyme into its desulpho-form. The rate of inactivation increases with nitrite concentration. Similar behaviour was shown when NADH replaced xanthine as reducing substrate. A kinetic model is proposed incorporating a 'suici...
متن کاملDietary Nitrate Ameliorates Pulmonary Hypertension: Cytoprotective Role for Endothelial Nitric Oxide Synthase and Xanthine Oxidoreductase Running title: Baliga et al.; Dietary nitrate in pulmonary hypertension
Background-Pulmonary hypertension (PH) is a multi-factorial disease characterized by
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ژورنال
عنوان ژورنال: Hypertension
سال: 2013
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.113.01826